![]() ![]() Results suggest that NS binds TNFα in vitro. DNA was extracted from feces and sorted for bacterial phylogenetic analysis. The three treatment groups included control, TNBS, and TNBS + NS. A TNBS mouse colitis model was utilized to study the efficacy of NS supplementation for 4 weeks. MethodsĮLISA, X-ray diffraction, and transmission electron microscopy were employed to characterize the NS–cytokine interaction in vitro. We also investigated whether NS could rescue gut microbial diversity in TNBS-induced mice. Herein, we report the ability of a refined dioctahedral smectite (NovaSil, NS) to sorb inflammatory proteins and reduce inflammation in a TNBS (2,4,6-trinitrobenzenesulfonic acid) mouse model of CD. ![]() ![]() Dioctahedral smectite clays have been utilized to treat medical conditions, including diarrheal and enteric disease. Consequently, alternative therapies that cause fewer systemic effects are needed. Available treatments frequently result in side effects that compromise the immune health of the patient. Five million people currently live with Crohn’s disease (CD) or ulcerative colitis, the two major forms of inflammatory bowel disease. ![]()
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